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非对映体β-内酰胺抗生素。分析方法、异构化和立体选择性药代动力学。

Diastereomeric beta-lactam antibiotics. Analytical methods, isomerization and stereoselective pharmacokinetics.

作者信息

Itoh T, Yamada H

机构信息

Department of Pharmacokinetics and Biopharmaceutics, School of Pharmaceutical Sciences, Kitasato University, Tokyo, Japan.

出版信息

J Chromatogr A. 1995 Mar 3;694(1):195-208. doi: 10.1016/0021-9673(94)00932-y.

DOI:10.1016/0021-9673(94)00932-y
PMID:7719465
Abstract

Stereospecific HPLC methods for the determination of various diastereomeric beta-lactam antibiotics are reviewed. Stereoselectivity in the absorption, distribution and excretion of several diastereomeric beta-lactams is summarized. The isomerization of beta-lactam isomers and its influence on the pharmacokinetics and pharmacodynamics are discussed.

摘要

综述了用于测定各种非对映体β-内酰胺抗生素的立体专一性高效液相色谱法。总结了几种非对映体β-内酰胺在吸收、分布和排泄方面的立体选择性。讨论了β-内酰胺异构体的异构化及其对药代动力学和药效学的影响。

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