精神分裂症与谷氨酸受体基因。

Schizophrenia and glutamate receptor genes.

作者信息

Pariseau C, Gregor P, Myles-Worsley M, Holik J, Hoff M, Waldo M, Freedman R, Coon H, Byerley W

机构信息

Department of Psychiatry, University of Utah Medical Center, Salt Lake City 84132.

出版信息

Psychiatr Genet. 1994 Fall;4(3):161-5. doi: 10.1097/00041444-199400430-00006.

DOI:10.1097/00041444-199400430-00006

PMID:7719702

Abstract

Nine multiplex schizophrenia families were genotyped with polymorphisms for the GLUR5 and NMDAR1 glutamate receptor subunit genes. Using the lod score technique, evidence of linkage was not found assuming either dominant or recessive transmission. Similarly, the non-parametric sib pair test did not yield significant evidence of linkage.

摘要

对9个多重精神分裂症家族进行了谷氨酸受体5（GLUR5）和N-甲基-D-天冬氨酸受体1（NMDAR1）亚基基因多态性的基因分型。采用对数优势分数（lod score）技术，在假设显性或隐性遗传模式下均未发现连锁证据。同样，非参数同胞对检验也未产生显著的连锁证据。