Lagios M D
Cancer Consultation Service, St. Mary's Medical Center, San Francisco, CA, USA.
Cancer Lett. 1995 Mar 23;90(1):97-102. doi: 10.1016/0304-3835(94)03683-a.
Morphologic analysis of nuclear grade and extent of necrosis can provide reproducible classification of subclinical duct carcinoma in situ (DCIS) which strongly separates DCIS into three risk groups. For subclinical lesions of small size, risk is largely limited to local recurrences only, half of which, however, are invasive events. Local recurrences are seen much more frequently with high grade DCIS. Most local recurrences following breast conservation therapy represent residual disease in the immediate vicinity of the biopsy site. Stromal and cellular host reactions may provide additional prognostic information.
对核分级和坏死范围进行形态学分析，可为亚临床导管原位癌（DCIS）提供可重复的分类，该分类能有力地将DCIS分为三个风险组。对于小尺寸的亚临床病变，风险主要局限于局部复发，不过其中一半为浸润性事件。高级别DCIS的局部复发更为常见。保乳治疗后的大多数局部复发代表活检部位紧邻区域的残留疾病。基质和细胞宿主反应可能提供额外的预后信息。
