Su Y H, Yang G L, Dong Y M
Department of Pathology, Anhui Medical University, Hefei.
Zhonghua Bing Li Xue Za Zhi. 1994 Dec;23(6):338-40.
By using light and electron microscopic histochemical techniques, the activities and distributions of ALP isoenzymes in gastric cancers and benign gastric diseases were examined. The results showed: Nagao, Regan and Kasahara isoenzymes, which were not expressed in normal gastric mucosae and non-malignant lesions, may be considered as the tumor markers of gastric cancer. The epithelium of intestinal metaplasia exhibited intestinal-type ALP only, which was one of the markers of well-differentiated intestinal metaplasia. In the view-point of the gene expression of ALP isoenzymes, two mutation hypothesis and recessive-gene mutation hypothesis may be proper for gastric cancer.
通过运用光镜和电镜组织化学技术，对胃癌及良性胃部疾病中碱性磷酸酶同工酶的活性和分布进行了检测。结果显示：正常胃黏膜和非恶性病变中未表达的长谷、里根和笠原同工酶，可被视为胃癌的肿瘤标志物。肠化生上皮仅表现出肠型碱性磷酸酶，这是高分化肠化生的标志物之一。从碱性磷酸酶同工酶的基因表达角度来看，双突变假说和隐性基因突变假说可能适用于胃癌。
