Bruze M, Hradil E, Eriksohn I L, Gruvberger B, Widström L
Department of Occupational Dermatology, General Hospital, Malmö, Sweden.
Contact Dermatitis. 1995 Jan;32(1):24-7. doi: 10.1111/j.1600-0536.1995.tb00835.x.
Alkanolamineborates are extensively used in coolants as corrosion inhibitors. In this paper, 3 machinists with contact allergy to alkanolamineborates are reported. To avoid false-positive test reactions due to the alkalinity of the alkanolamineborates, they should be tested when dissolved in an acidic buffer. When various alkanolamineborates were tested in dilution series in the 3 patients, 2 types of reactivity patterns emerged, indicating the existence of at least 2 separate sensitizers in alkanolamineborates. The raw materials, ethanolamines and boric acid, did not yield any positive patch test reactions. Thin-layer chromatography investigations demonstrated that each alkanolamineborate consists of many substances, which differed in part between different alkanolamineborates. The present study shows that it is not possible to use 1 particular alkanolamineborate for tracing contact allergy to alkanolamineborates in general.
链烷醇胺硼酸盐作为缓蚀剂广泛应用于冷却液中。本文报道了3名对链烷醇胺硼酸盐有接触性过敏的机械师。为避免因链烷醇胺硼酸盐的碱性导致假阳性试验反应，应在其溶解于酸性缓冲液中时进行检测。当对这3名患者进行不同链烷醇胺硼酸盐的系列稀释检测时，出现了2种反应模式，表明链烷醇胺硼酸盐中至少存在2种不同的致敏原。其原料乙醇胺和硼酸未产生任何阳性斑贴试验反应。薄层色谱研究表明，每种链烷醇胺硼酸盐都由多种物质组成，不同链烷醇胺硼酸盐中的这些物质部分存在差异。本研究表明，一般情况下，不能用某一种特定的链烷醇胺硼酸盐来追踪对链烷醇胺硼酸盐的接触性过敏。
