Yemini M, Vanderzwalmen P, Mukaida T, Schoengold S, Birkenfeld A
Diamond Institute for Infertility and Menopause, Irvington, New Jersey 07111, USA.
Fertil Steril. 1995 May;63(5):1118-20. doi: 10.1016/s0015-0282(16)57559-1.
To achieve fertilization and cleavage by spermatozoa retrieved by testicular biopsy from a male with testicular tubular atrophy.
Clinical trial.
Private reproductive institute.
Azoospermic male with demonstrated testicular tubular atrophy and almost complete spermatogenic arrest.
Open biopsy retrieval of testicular tissue and sperm followed by intracytoplasmic sperm injection.
Fertilization and cleavage.
One four- to six-cell embryo was formed after intracytoplasmic sperm injection of five eggs with extruded polar bodies by retrieved sperm.
Intracytoplasmic sperm injection after testicular sperm aspiration may be attempted in cases with severely decreased spermatogenesis and result in fertilization, cleavage, and embryo transfer.
通过睾丸活检从患有睾丸小管萎缩的男性中获取精子，以实现受精和卵裂。
临床试验。
私立生殖机构。
一名无精子症男性，经证实存在睾丸小管萎缩且几乎完全生精停滞。
通过开放式活检获取睾丸组织和精子，随后进行卵胞浆内单精子注射。
受精和卵裂。
用获取的精子对5个排出极体的卵子进行卵胞浆内单精子注射后，形成了1个4至6细胞胚胎。
对于精子发生严重减少的病例，可尝试在睾丸精子抽吸后进行卵胞浆内单精子注射，其可能导致受精、卵裂并可进行胚胎移植。
