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[摩尔多瓦中部居民的基因结构]

[Genetic structure of the residents of Central Moldova].

作者信息

Kovtiukh L P

出版信息

Genetika. 1995 Feb;31(2):250-8.

PMID:7721066
Abstract

Distributions of the marker genes for (1) blood groups ABO, Rhesus, MN, P, and Lewis; (2) some allotypes of G1m immunoglobulin; and (3) serum proteins Hp, Tf, and Gc; and (4) erythrocytic isoenzymes Acp and EsD were studied in 10 rural populations of central Moldova. For each local population, an empirical distribution of genotypes was obtained; and on this basis, allele frequencies, expected distributions of genotypes, and observed and expected heterozygosity were estimated. Significant differences between the studied populations with respect to variations of allele frequencies were found for the following loci: Hp, AcP, Gc, P, G1m, and Lewis. The results were compared with data on some populations of Western Europe and the CIS. Close relationships between indigenous Moldovans and other Romanic peoples, as well as the Russians and the Ukrainians, were demonstrated.

摘要

对摩尔多瓦中部10个农村人口的以下标记基因分布进行了研究:(1) ABO、恒河猴、MN、P和Lewis血型;(2) G1m免疫球蛋白的一些同种异型;(3) 血清蛋白Hp、Tf和Gc;以及(4) 红细胞同工酶Acp和EsD。对于每个当地人群,获得了基因型的经验分布;并在此基础上,估计了等位基因频率、基因型的预期分布以及观察到的和预期的杂合度。在所研究的人群之间,发现以下基因座的等位基因频率变化存在显著差异:Hp、AcP、Gc、P、G1m和Lewis。将结果与西欧和独联体一些人群的数据进行了比较。结果表明,摩尔多瓦原住民与其他罗曼语族人群以及俄罗斯人和乌克兰人之间关系密切。

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