Norazmi M N, Suarn S
Department of Immunology, School of Medical Sciences, Universiti Sains Malaysia, Kelantan.
Immunol Lett. 1994 Dec;43(3):177-82. doi: 10.1016/0165-2478(94)90219-4.
The CD4+ T-lymphocyte absolute count (CD4ac), CD4+ T-lymphocyte percentage (CD4%) and total lymphocyte count (Løac) were assessed in HIV-seropositive intravenous drug users (IVDU) with reference to their correlation with the clinical categories A, B, and C as stipulated by the Centre of Disease Control and Prevention, USA (CDC) and with each other. It was found that while the CD4ac and Løac correlated with the clinical categories, CD4% did not. This may suggest that in our local setting, the CD4% may not necessarily be a suitable alternative marker to CD4ac as proposed by CDC. Furthermore, the CD4% of the normal subjects in this study was found to be relatively lower than the reported Caucasian levels. This may indicate that the use of the cut-off level of less than 14% as an AIDS-defining criteria may not be applicable for our HIV-seropositive IVDU. In addition, unlike the CD4ac which correlated directly with CD4% and Løac, the CD4% did not correlate with Løac. Therefore, due to the observed disparity with clinical status of patients and its possibly lower levels in our normal population, CD4% as a marker for staging HIV disease should be used with caution in our setting. Such findings may also have an impact on the use of established markers for the monitoring and classification of HIV-infected individuals in this region.
对HIV血清反应呈阳性的静脉注射吸毒者（IVDU）的CD4 + T淋巴细胞绝对计数（CD4ac）、CD4 + T淋巴细胞百分比（CD4%）和总淋巴细胞计数（Løac）进行了评估，参考了它们与美国疾病控制与预防中心（CDC）规定的A、B、C临床类别之间的相关性以及它们相互之间的相关性。结果发现，虽然CD4ac和Løac与临床类别相关，但CD4%却不然。这可能表明，在我们当地的环境中，CD4%不一定是CDC所提议的CD4ac的合适替代标志物。此外，本研究中正常受试者的CD4%相对低于所报道的白种人水平。这可能表明，将低于14%的临界值用作艾滋病定义标准可能不适用于我们的HIV血清反应呈阳性的IVDU。此外，与直接与CD4%和Løac相关的CD4ac不同，CD4%与Løac不相关。因此，由于观察到与患者临床状况的差异以及其在我们正常人群中可能较低的水平，在我们的环境中，将CD4%作为HIV疾病分期的标志物应谨慎使用。这些发现也可能对该地区用于监测和分类HIV感染者的既定标志物的使用产生影响。
