Patel M, Selinger D, Mark G E, Hickey G J, Hollis G F
Department of Cellular and Molecular Biology, Merck Research Laboratories, Rahway, NJ 07065, USA.
Immunogenetics. 1995;41(5):282-6. doi: 10.1007/BF00172152.
The immunoglobulin alpha (IGHAC) and epsilon (IGHEC) germline constant region genes were isolated from a dog liver genomic DNA library. Sequence analysis indicates that the dog IGHEC gene is encoded by four exons spread out over 1.7 kilobases (kb). The IGHAC sequence encompasses 1.5 kb and includes all three constant region coding exons. The complete exon/intron sequence of these genes is described.
免疫球蛋白α(IGHAC)和ε(IGHEC)种系恒定区基因是从犬肝脏基因组DNA文库中分离出来的。序列分析表明,犬IGHEC基因由分布在1.7千碱基(kb)上的四个外显子编码。IGHAC序列全长1.5 kb,包含所有三个恒定区编码外显子。本文描述了这些基因完整的外显子/内含子序列。