Flanagan J G, Rabbitts T H
Nature. 1982 Dec 23;300(5894):709-13. doi: 10.1038/300709a0.
Cosmid clones containing the human gamma, epsilon and alpha heavy chain constant region genes and an epsilon pseudogene have been isolated. All these genes have a switch sequence detectable by hybridization. We have studied overlapping cosmids covering two separate regions of the genome, and the gene order in each of these regions was found to be gamma-gamma-epsilon-alpha. This implies an evolutionary duplication in this multigene family involving gamma, epsilon and alpha genes.
已分离出包含人类γ、ε和α重链恒定区基因以及一个ε假基因的黏粒克隆。所有这些基因都有一个可通过杂交检测到的转换序列。我们研究了覆盖基因组两个不同区域的重叠黏粒，发现每个区域的基因顺序都是γ-γ-ε-α。这意味着在这个涉及γ、ε和α基因的多基因家族中存在进化复制。
