Karvonen M, Tuomilehto J, Pitkäniemi J, Naukkarinen A, Saikku P
Department of Epidemiology and Health Promotion, National Public Health Institute, Helsinki, Finland.
Int J Epidemiol. 1994 Dec;23(6):1315-21. doi: 10.1093/ije/23.6.1315.
Population-based studies of the association between smoking and Chlamydia pneumoniae seropositivity do not exist. The role of smoking in the association between C. pneumoniae seropositivity and coronary artery disease (CAD) suggested by several studies has been debated. The aim of this study was to determine the relationship between smoking habits and C. pneumoniae IgG antibody titres in a middle-aged population. We also wanted to find out whether the difference in smoking habits between the sexes explains the higher C. pneumoniae antibody prevalence among men compared with women.
After controlling for the effect of smoking, the risk of C. pneumoniae seropositivity remained 1.4 times higher in men than in women. In men, the estimated risk for C. pneumoniae seropositivity (titre > or = 1:16) was significant only for smokers (adjusted odds ratio [OR] = 1.4). The adjusted OR for high seropositivity (titre > or = 1:128) was 1.5 for smokers and 1.7 for ex-smokers. The risk for women was similar to that for men.
The results provide evidence of an association between smoking and C. pneumoniae seropositivity in the general population. The higher prevalence of smoking in men does not explain the C. pneumoniae antibody prevalence in men compared with women.
目前尚无基于人群的吸烟与肺炎衣原体血清阳性之间关联的研究。多项研究提示的吸烟在肺炎衣原体血清阳性与冠状动脉疾病（CAD）关联中的作用一直存在争议。本研究的目的是确定中年人群中吸烟习惯与肺炎衣原体IgG抗体滴度之间的关系。我们还想了解性别间吸烟习惯的差异是否能解释男性肺炎衣原体抗体患病率高于女性的现象。
在控制吸烟影响后，男性肺炎衣原体血清阳性的风险仍比女性高1.4倍。在男性中，仅吸烟者肺炎衣原体血清阳性（滴度≥1:16）的估计风险具有统计学意义（调整优势比[OR]=1.4）。高血清阳性（滴度≥1:128）的调整OR值，吸烟者为1.5，既往吸烟者为1.7。女性的风险与男性相似。
结果为一般人群中吸烟与肺炎衣原体血清阳性之间的关联提供了证据。男性吸烟率较高并不能解释男性与女性相比肺炎衣原体抗体的患病率。
