Charlson M, Szatrowski T P, Peterson J, Gold J
Department of Medicine, Cornell Arthritis and Musculoskeletal Disease Center, Hospital for Special Surgery, New York, NY, USA.
J Clin Epidemiol. 1994 Nov;47(11):1245-51. doi: 10.1016/0895-4356(94)90129-5.
The basic objective of this paper is to evaluate an age-comorbidity index in a cohort of patients who were originally enrolled in a prospective study to identify risk factors for peri-operative complications. Two-hundred and twenty-six patients were enrolled in the study. The participants were patients with hypertension or diabetes who underwent elective surgery between 1982 and 1985 and who survived to discharge. Two-hundred and eighteen patients survived until discharge. These patients were followed for at least five years post-operatively. The estimated relative risk of death for each comorbidity rank was 1.4 and for each decade of age was 1.4. When age and comorbidity were modelled as a combined age-comorbidity score, the estimated relative risk for each combined age-comorbidity unit was 1.45. Thus, the estimated relative risk of death from an increase of one in the comorbidity score proved approximately equal to that from an additional decade of age. The combined age-comorbidity score may be useful in some longitudinal studies to estimate relative risk of death from prognostic clinical covariates.
本文的基本目标是在一组最初纳入前瞻性研究以确定围手术期并发症风险因素的患者中评估年龄-合并症指数。该研究共纳入了226名患者。参与者为患有高血压或糖尿病的患者，他们在1982年至1985年间接受了择期手术且存活至出院。218名患者存活至出院。这些患者术后至少随访了五年。每个合并症等级的估计死亡相对风险为1.4，每增加十岁的估计死亡相对风险为1.4。当将年龄和合并症建模为综合年龄-合并症评分时，每个综合年龄-合并症单位的估计相对风险为1.45。因此，合并症评分增加一分导致的估计死亡相对风险与年龄增加十岁导致的估计死亡相对风险大致相当。综合年龄-合并症评分在一些纵向研究中可能有助于根据预后临床协变量估计死亡相对风险。
