Fuller R K, Mattson M E, Allen J P, Randall C L, Anton R F, Babor T F
National Institute on Alcohol Abuse and Alcoholism, Rockville, Maryland 20892-7003.
J Stud Alcohol Suppl. 1994 Dec;12:30-7. doi: 10.15288/jsas.1994.s12.30.
Multisite clinical trials have two major advantages over single-site studies: the large sample size of multisite studies allows for adequate statistical power and better representativeness of the population being studied. However, they are more complex to implement than single-site studies. This article reviews previous multisite clinical trials of alcohol abuse and alcoholism, reasons for selecting a multisite design, management of such studies, and some statistical issues.
