Palmer A C, Cavanagh J B
Wellcome Laboratory for Comparative Neurology, School of Veterinary Medicine, Cambridge, London.
J Small Anim Pract. 1995 Feb;36(2):57-64. doi: 10.1111/j.1748-5827.1995.tb02822.x.
Nineteen cats, aged three to 16 months, developed neurological signs including hindleg paralysis, head shaking, nystagmus, defective vision and reduced proprioception. Most of the animals were in cat colonies in research centres and were derived from specific pathogen-free stock. One was referred from veterinary practice. Over 40 per cent of litters could be affected constituting a serious commercial loss. Wallerian degeneration affected long tracts in the spinal cord and variously in the brain stem and cerebral white matter. In seven animals there was loss of Purkinje cells in the cerebellum and in eight there was neuronal loss in the spinal cord. Gliosis accompanied all changes. Although no viral agent was isolated the clinical pattern of the disease and evidence from other cases reported in the literature suggest an infectious cause.
19只3至16个月大的猫出现了神经症状，包括后肢麻痹、头部摇晃、眼球震颤、视力缺陷和本体感觉减退。大多数动物来自研究中心的猫群，源自无特定病原体的种群。有一只猫是从兽医诊所转诊而来的。超过40%的猫窝可能受到影响，造成严重的商业损失。华勒氏变性影响脊髓中的长传导束，在脑干和脑白质中也有不同程度的影响。7只动物的小脑浦肯野细胞丢失，8只动物的脊髓出现神经元丢失。所有病变均伴有胶质增生。虽然未分离出病毒病原体，但该病的临床症状以及文献中报道的其他病例证据提示其病因具有传染性。
