Barry M K, Aloisi J D, Yeo C J
Department of Surgery, Johns Hopkins Medical Institution, Baltimore, Maryland, USA.
J Surg Res. 1995 Apr;58(4):425-31. doi: 10.1006/jsre.1995.1066.
The ingestion of a meal stimulates absorption from the jejunal lumen and is dependent on intact neural pathways. Few studies of ileal absorptive responses to a meal have been performed. This study tested two hypotheses: (1) a meal stimulates ileal glucose, water, and ion absorption, and (2) intact intestinal neurotransmission is necessary to maintain the basal and meal-stimulated absorptive states in the ileum. Absorption studies (n = 50) using 14C-labeled PEG were performed on six dogs with 25-cm ileal Thiry-Vella fistulas (TVF). Four groups were randomly studied over 4 hr. Intraluminal oxethazaine (2 mg/dl) was administered to the TVF in Groups 2 and 4 after the 1st hour to produce neural blockade. A control volume of water was administered to the TVF in Groups 1 and 3 after the 1st hour. A 480 kcal meal was ingested at the end of the 2nd hour in groups 3 and 4. Ileal water, ion, and glucose absorption were increased significantly (P < 0.05) by the ingestion of a meal. TVF oxethazaine significantly reduced (P < 0.05) basal water and ion absorption but had no effect on meal-stimulated absorption. Ileal absorption of water, ions, and glucose is significantly increased by the ingestion of a meal. Basal ileal absorption appears to be partly dependent upon intact neurotransmission. Postprandial ileal absorption appears to be independent of neural blockade, implicating circulating hormones, paracrine mediators, or neurotransmission within the myenteric plexus of the enteric nervous system as the primary modulators of meal-stimulated ileal absorption.
进食一顿饭会刺激空肠腔内的吸收，且这依赖于完整的神经通路。针对回肠对进食的吸收反应所开展的研究较少。本研究检验了两个假设：（1）一顿饭会刺激回肠对葡萄糖、水和离子的吸收；（2）完整的肠道神经传递对于维持回肠的基础吸收状态及进食刺激后的吸收状态是必要的。对六只患有25厘米回肠Thiry-Vella瘘管（TVF）的狗进行了使用14C标记聚乙二醇（PEG）的吸收研究（n = 50）。在4小时内对四组进行了随机研究。在第1小时后，向第2组和第4组的TVF中给予腔内奥昔卡因（2毫克/分升）以产生神经阻滞。在第1小时后，向第1组和第3组的TVF中给予对照体积的水。在第2小时末，第3组和第4组摄入一顿480千卡的餐食。进食一顿饭显著增加了（P < 0.05）回肠对水、离子和葡萄糖的吸收。TVF中的奥昔卡因显著降低了（P < 0.05）基础水和离子吸收，但对进食刺激后的吸收没有影响。进食一顿饭会显著增加回肠对水、离子和葡萄糖的吸收。基础回肠吸收似乎部分依赖于完整的神经传递。餐后回肠吸收似乎独立于神经阻滞，这表明循环激素、旁分泌介质或肠神经系统肌间神经丛内的神经传递是进食刺激回肠吸收的主要调节因子。
