Yoshino K, Endo M, Ishikawa N, Takahashi Y
Department of Surgery, Tokyo Medical and Dental University, Japan.
J Surg Oncol. 1995 Apr;58(4):246-51. doi: 10.1002/jso.2930580410.
The esophagus and the head and neck region, both having the squamous epithelium, are thought to be subject to the same carcinogenic factors. This report discusses the diagnosis and treatment of secondary cancer detected following the treatment of primary cancer in 21 patients who had metachronous cancer comprising esophageal cancer and head and neck cancer. The secondary cancer was already advanced when detected despite the fact that almost all patients were followed up regularly at the outpatient clinic of the facility where the primary cancer was treated. Although surgical treatment of the secondary cancer was similar to that of the usual primary cancer, the prognosis for the former was poor, indicating that the prognosis tends to be determined by the disease stage of the secondary cancer. Early detection of the secondary cancer requires esophagoscopy using the iodine dye method or close examination of the head and neck region at an otolaryngologic outpatient clinic at the time of treatment of the primary cancer and thereafter at 6- to 12-month intervals.
食管以及头颈部区域均为鳞状上皮，被认为会受到相同致癌因素的影响。本报告探讨了21例患有包括食管癌和头颈部癌在内的异时性癌的患者，在原发性癌症治疗后检测到的继发性癌症的诊断和治疗情况。尽管几乎所有患者都在治疗原发性癌症的机构的门诊定期接受随访，但继发性癌症在被检测到时已处于晚期。虽然继发性癌症的手术治疗与普通原发性癌症相似，但其预后较差，这表明预后往往由继发性癌症的疾病阶段决定。继发性癌症的早期检测需要在原发性癌症治疗时以及之后每隔6至12个月，使用碘染法进行食管镜检查或在耳鼻喉科门诊对头颈部区域进行仔细检查。
