Shinozaki H, Minegishi T, Nakamura K, Tano M, Miyamoto K, Ibuki Y
Department of Obstetrics and Gynecology, Gunma University School of Medicine, Japan.
Life Sci. 1995;56(20):1699-706. doi: 10.1016/0024-3205(95)98576-2.
The expression of type II activin receptor(ActRII) and type IIB activin receptor(ActRIIB) messenger RNA(mRNA) in different stages of development of the human placenta was examined by Northern blot analysis. In our experiments, the first trimester placenta showed the highest levels of ActRIIB expression and human placenta from different stages expressed both type II and IIB activin receptor mRNAs. These observations support the hypothesis that activin might act as a paracrine/autocrine factor in human placenta and activin might have stage specific functions through the different types of receptors.
通过Northern印迹分析检测了人胎盘不同发育阶段II型激活素受体（ActRII）和IIB型激活素受体（ActRIIB）信使核糖核酸（mRNA）的表达。在我们的实验中，孕早期胎盘显示出最高水平的ActRIIB表达，并且来自不同阶段的人胎盘均表达II型和IIB型激活素受体mRNA。这些观察结果支持以下假说：激活素可能作为人胎盘中的旁分泌/自分泌因子，并且激活素可能通过不同类型的受体发挥阶段特异性功能。
