Tonstad S, Holdaas H, Gørbitz C, Ose L
Lipid Clinic, National Hospital, Oslo, Norway.
Nephrol Dial Transplant. 1995;10(1):82-5.
Current therapies for hyperlipidaemia following renal transplantation include modification of dietary fat. We examined the effect of dietary intervention according to the American Heart Association Step One diet on serum lipids and lipoproteins among 26 men and women with post-transplant hyperlipidaemia. Weighed dietary records showed that the intake of total fat decreased from 30 to 27% and the intake of saturated fat decreased from 12 to 8% of total calories. Body-weight remained stable throughout the study. Serum total, LDL and HDL cholesterol levels were unchanged following 12 weeks of therapy. Serum triglyceride levels decreased slightly. The decrease was seen only in participants with a body mass index < 26 kg/m2, compared to those whose body mass index was > or = 26 kg/m2 (0.4 versus 0 mmol/l; P = 0.03). Serum LDL cholesterol and triglyceride levels were significantly correlated with serum creatinine levels. In conclusion, among renal transplant recipients, hyperlipidaemia appears to be partly related to impairment of renal function, and may not be responsive to modification of dietary fat without weight reduction attempted on an outpatient basis.
目前肾移植后高脂血症的治疗方法包括调整饮食脂肪。我们根据美国心脏协会第一步饮食方案，对26名肾移植后高脂血症的男性和女性进行饮食干预，观察其对血脂和脂蛋白的影响。称重饮食记录显示，总脂肪摄入量从占总热量的30%降至27%，饱和脂肪摄入量从12%降至8%。在整个研究过程中体重保持稳定。治疗12周后，血清总胆固醇、低密度脂蛋白胆固醇和高密度脂蛋白胆固醇水平未发生变化。血清甘油三酯水平略有下降。与体重指数≥26kg/m²的参与者相比，仅体重指数<26kg/m²的参与者出现了下降（0.4对0mmol/l；P=0.03）。血清低密度脂蛋白胆固醇和甘油三酯水平与血清肌酐水平显著相关。总之，在肾移植受者中，高脂血症似乎部分与肾功能损害有关，在门诊未尝试减轻减轻减轻体重的情况下，可能对饮食脂肪的调整无反应。
