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比较两种饮食干预对高脂血症患者有效性的随机临床试验。

Randomized clinical trial comparing the effectiveness of two dietary interventions for patients with hyperlipidaemia.

作者信息

Mhurchú C N, Margetts B M, Speller V

机构信息

Wessex Institute for Health Research and Development, Level B, South Academic Block, Southampton General Hospital, Southampton SO16 6YD, U.K.

出版信息

Clin Sci (Lond). 1998 Oct;95(4):479-87.

PMID:9748424
Abstract
  1. Intervention trials in free-living populations have shown relatively small reductions in risk factors for cardiovascular disease, including lipid levels, and have led some to question whether diet is an effective treatment for hyperlipidaemia. However, behaviour change is a complex process and it is possible that standard intervention methods fail to motivate people sufficiently to comply with dietary advice.2. This study applied motivational interviewing, a style of behaviour change counselling, to dietary education for people with hyperlipidaemia. One-hundred and twenty-one patients with hyperlipidaemia who had been referred to a hospital dietetic department for dietary advice were randomized to receive either standard or motivational dietary interventions for a period of 3 months. Outcomes assessed included dietary knowledge, stage of change, dietary intakes, lipid levels and body mass indices. 3. From baseline, both methods of dietary intervention resulted in self-reported changes in dietary habits and knowledge, statistically significant reductions in intake of total fat (from 32.8% to 28.4%), saturated fat (from 11.4% to 9.2%) and energy intakes [-239 kcal (-999.98 kJ)/day], and in body mass indices (-0.45 kg/m2). Serum cholesterol did not change significantly in either intervention group.4. Motivational and standard dietary interventions achieved statistically significant changes in reported dietary knowledge and behaviour, and led to a reduction in body weight, but not serum cholesterol. Whether this lack of effect is real or due to subjects overestimating true dietary change cannot be determined. Change in body weight was associated with a reported change in energy intake; this provides some support for there having been a real change in intake.
摘要
  1. 针对自由生活人群的干预试验表明,心血管疾病风险因素(包括血脂水平)的降低幅度相对较小,这使得一些人质疑饮食是否是治疗高脂血症的有效方法。然而,行为改变是一个复杂的过程,标准干预方法可能无法充分激励人们遵守饮食建议。

  2. 本研究将动机性访谈(一种行为改变咨询方式)应用于高脂血症患者的饮食教育。121名因饮食建议被转诊至医院饮食科的高脂血症患者被随机分为两组,分别接受为期3个月的标准饮食干预或动机性饮食干预。评估的结果包括饮食知识、改变阶段、饮食摄入量、血脂水平和体重指数。

  3. 从基线水平来看,两种饮食干预方法均导致了饮食习惯和知识的自我报告变化,总脂肪摄入量(从32.8%降至28.4%)、饱和脂肪摄入量(从11.4%降至9.2%)和能量摄入量[ -239千卡(-999.98千焦)/天]以及体重指数(-0.45千克/平方米)在统计学上有显著降低。两个干预组的血清胆固醇均无显著变化。

  4. 动机性饮食干预和标准饮食干预在报告的饮食知识和行为方面取得了统计学上的显著变化,并导致体重下降,但血清胆固醇未下降。这种缺乏效果是真实的还是由于受试者高估了实际饮食变化尚无法确定。体重变化与报告的能量摄入量变化相关;这为摄入量确实发生了变化提供了一些支持。

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