Ledoux D R, Bermudez A J, Rottinghaus G E, Broomhead J, Bennett G A
Fusarium/Poultry Research Laboratory, University of Missouri, Columbia 65211, USA.
Poult Sci. 1995 Feb;74(2):297-305. doi: 10.3382/ps.0740297.
An experiment was conducted with 270 male broiler chicks to evaluate the effects of a Fusarium fujikuroi M-1214 culture material containing moniliformin (M) on broiler chicks. Day-old chicks were allotted randomly to dietary treatments containing 0, .24, .48, .72, .96, 1.44, 1.92, 2.40, and 2.88% M culture material (MCM). These levels of MCM supplied 0, 25, 50, 75, 100, 150, 200, 250, or 300 mg M/kg of feed. Each dietary treatment was fed to six pen replicates of five chicks per pen for 21 d. Significant mortality (P < .05) occurred in chicks fed 200 (8 out of 30), 250 (17 out of 30), and 300 (25 out of 30) mg M/kg feed. Chicks fed > 100 mg M/kg had lower (P < .05) feed intakes and smaller BW gains (P < .05) than controls. Increased heart weights (P < .05) were observed in chicks fed > 50 mg M/kg, and increased liver weights (P < .05) in chicks fed > 100 mg M/kg. Gross lesions of M toxicity included generalized cardiomegaly with dilation of the right ventricle. Histopathology revealed a high incidence of large and variably shaped cardiomyocyte nuclei and a generalized loss of cardiomyocyte cross striations in chicks fed > 75 and 200 mg M/kg, respectively. Results indicated that F. fujikuroi culture material containing M is toxic to young broiler chicks.
用270只雄性肉仔鸡进行了一项实验，以评估含有串珠镰刀菌素（M）的藤仓镰刀菌M - 1214培养物对肉仔鸡的影响。将一日龄雏鸡随机分配到含有0、0.24、0.48、0.72、0.96、1.44、1.92、2.40和2.88% M培养物（MCM）的日粮处理组中。这些MCM水平分别提供0、25、50、75、100、150、200、250或300毫克M/千克饲料。每个日粮处理组饲喂6个重复栏，每栏5只雏鸡，共21天。饲喂200（30只中有8只）、250（30只中有17只）和300（30只中有25只）毫克M/千克饲料的雏鸡出现显著死亡率（P < 0.05）。饲喂>100毫克M/千克的雏鸡比对照组的采食量更低（P < 0.05），体重增加更小（P < 0.05）。饲喂>50毫克M/千克的雏鸡心脏重量增加（P < 0.05），饲喂>100毫克M/千克的雏鸡肝脏重量增加（P < 0.05）。M中毒的大体病变包括全身性心脏肥大伴右心室扩张。组织病理学显示，分别饲喂>75和200毫克M/千克的雏鸡中，大的和形状各异的心肌细胞核发生率高，心肌细胞横纹普遍消失。结果表明，含有M的藤仓镰刀菌培养物对幼龄肉仔鸡有毒性。
