Bunge A L, Cleek R L
Chemical Engineering and Petroleum Refining Department, Colorado School of Mines, Golden 80401, USA.
Pharm Res. 1995 Jan;12(1):88-95. doi: 10.1023/a:1016242821610.
A new method for estimating dermal absorption including the effects of exposure time and chemistry is described generally in Part 1 of this series. This method accounts for the larger absorption rates during the initial exposure period as well as the hydrophilic barrier which the viable epidermis presents to lipophilic chemicals. A key parameter in this procedure, the ratio of the stratum corneum and epidermis permeabilities (B) depends on molecular weight and octanol-water partitioning. Several approaches for approximating B and its affect on the dermal absorption prediction are discussed here. Generally, the parameter B is only important for highly lipophilic chemicals which also have relatively small molecular weights. When B is important, the recommended prediction for B is based on the Potts and Guy correlation for human stratum corneum permeability.
本系列第1部分总体介绍了一种估算皮肤吸收的新方法，该方法考虑了暴露时间和化学物质的影响。此方法说明了初始暴露期较大的吸收率以及有活力的表皮对亲脂性化学物质所呈现的亲水性屏障。该程序中的一个关键参数，即角质层与表皮渗透率之比（B），取决于分子量和正辛醇 - 水分配系数。本文讨论了几种估算B及其对皮肤吸收预测影响的方法。一般来说，参数B仅对分子量相对较小的高亲脂性化学物质很重要。当B很重要时，推荐基于Potts和Guy关于人体角质层渗透率的相关性来预测B。
