Onuchic J N, Wolynes P G, Luthey-Schulten Z, Socci N D
School of Chemical Sciences, University of Illinois, Urbana 61801, USA.
Proc Natl Acad Sci U S A. 1995 Apr 11;92(8):3626-30. doi: 10.1073/pnas.92.8.3626.
Experimental information on the structure and dynamics of molten globules gives estimates for the energy landscape's characteristics for folding highly helical proteins, when supplemented by a theory of the helix-coil transition in collapsed heteropolymers. A law of corresponding states relating simulations on small lattice models to real proteins possessing many more degrees of freedom results. This correspondence reveals parallels between "minimalist" lattice results and recent experimental results for the degree of native character of the folding transition state and molten globule and also pinpoints the needs of further experiments.
当结合塌缩杂聚物中螺旋-线团转变理论时，关于熔球态结构和动力学的实验信息给出了折叠高度螺旋化蛋白质时能量景观特征的估计。由此得出了一个对应态定律，该定律将小晶格模型上的模拟与具有更多自由度的真实蛋白质联系起来。这种对应揭示了“极简主义”晶格结果与折叠过渡态和熔球态天然特征程度的近期实验结果之间的相似性，也指出了进一步实验的需求。
