Velázquez Martínez D N, Valencia Flores M, López Cabrera M, Villarreal J E
Departamento de Psicofisiología, Facultad de Psicología, Universidad Nacional Autónoma de México, México D.F.
Psychopharmacology (Berl). 1995 Jan;117(1):91-101. doi: 10.1007/BF02245103.
Indorenate (TR3369, 5-methoxytryptamine b-methylcarboxylate HCl) is a 5-HT1-like receptor agonist with hypotensive activity. Here, we describe that indorenate also decreases food intake (ED50 26.1 mg/kg) without an appreciable effect in water intake (the estimated ED50 for water was 589.8 mg/kg). The anorectic activity of indorenate was compared to the effects of amphetamine and other serotonin agonists; the effect of indorenate was smaller than those of the other compounds; however, the effect of indorenate was specific to food, whereas all the other drugs also produced significant decrements in water intake. The serotonin antagonists cinanserin, cyproheptadine, methergoline and methysergide effectively prevented the decrease in food intake produced by indorenate and fenfluramine. Haloperidol, a dopaminergic antagonist, was ineffective in preventing the effect of indorenate although it prevented the anorectic effect of amphetamine. The present results suggest the participation of serotoninergic, but not dopaminergic mechanisms, in the decrease in food intake produced by indorenate.
吲哚雷尼（TR3369，5-甲氧基色胺盐酸β-甲酯）是一种具有降压活性的5-HT1样受体激动剂。在此，我们描述吲哚雷尼还能减少食物摄入量（半数有效量为26.1毫克/千克），而对水摄入量没有明显影响（估计水的半数有效量为589.8毫克/千克）。将吲哚雷尼的厌食活性与苯丙胺和其他血清素激动剂的作用进行了比较；吲哚雷尼的作用小于其他化合物；然而，吲哚雷尼的作用对食物具有特异性，而所有其他药物也会使水摄入量显著减少。血清素拮抗剂辛那色林、赛庚啶、麦角苄酯和甲基麦角新碱可有效防止吲哚雷尼和芬氟拉明引起的食物摄入量减少。多巴胺能拮抗剂氟哌啶醇虽然能防止苯丙胺的厌食作用，但对防止吲哚雷尼的作用无效。目前的结果表明，血清素能机制而非多巴胺能机制参与了吲哚雷尼引起的食物摄入量减少。
