Fuller R W, Yen T T, Stamm N B
Clin Exp Hypertens (1978). 1981;3(3):497-508. doi: 10.3109/10641968109033678.
1-(m-Trifluoromethylphenyl)piperazine, a serotonin agonist, lowered blood pressure in spontaneously hypertensive rats (SHR) at doses of 2 to 10 mg/kg s.c. A structurally related compound lacking serotonin agonist activity, 4-(m-trifluoromethylphenyl)piperidine, was ineffective. Quipazine, another serotonin agonist, lowered blood pressure in SHR at doses of 0.1 to 2 mg/kg s.c. Fenfluramine, a serotonin-releasing drug, lowered blood pressure in SHR at doses of 2 and 5 mg/kg s.c. Metergoline (3 mg/kg s.c.), a serotonin antagonist, elevated blood pressure and prevented the decrease by all of the above agents. These findings are consistent with the view that enhancement of central serotonergic function lowers blood pressure in SHR.
1-（间三氟甲基苯基）哌嗪，一种血清素激动剂，以2至10毫克/千克的皮下注射剂量可降低自发性高血压大鼠（SHR）的血压。一种缺乏血清素激动剂活性的结构相关化合物，4-（间三氟甲基苯基）哌啶，没有效果。另一种血清素激动剂喹哌嗪，以0.1至2毫克/千克的皮下注射剂量可降低SHR的血压。芬氟拉明，一种血清素释放药物，以2和5毫克/千克的皮下注射剂量可降低SHR的血压。麦角新碱（3毫克/千克皮下注射），一种血清素拮抗剂，可升高血压并阻止上述所有药物引起的血压下降。这些发现与以下观点一致，即增强中枢血清素能功能可降低SHR的血压。
