Stollfuss J C, Glatting G, Friess H, Kocher F, Berger H G, Reske S N
Department of Nuclear Medicine, University of Ulm, Germany.
Radiology. 1995 May;195(2):339-44. doi: 10.1148/radiology.195.2.7724750.
To evaluate use of positron emission tomography (PET) versus computed tomography (CT) in detection of pancreatic cancer and determine the value of quantitative and visual image interpretation of these techniques.
Within 8 weeks before surgery, 73 patients with suspected pancreatic cancer or chronic pancreatitis underwent imaging with CT and with static PET after injection of 250-350 MBq of 2-(fluorine-18)-fluoro-2-deoxy-D-glucose (FDG). Focal FDG uptake, considered a sign of malignancy, was calculated with standardized uptake values (SUVs) 60 minutes after injection.
With FDG PET, pancreatic carcinoma was correctly diagnosed in 41 (95%) of 43 patients, and chronic pancreatitis in 27 (90%) of 30 patients. With an SUV cutoff value of 1.53, both sensitivity and specificity for detection of malignancy were 93%. With CT, pancreatic cancer was correctly diagnosed in 33 (80%) of 41 patients, whereas results in seven (26%) of 27 patients with chronic pancreatitis were false-positive (specificity, 74%).
FDG PET enabled reliable differentiation of pancreatic adenocarcinoma from chronic pancreatitis. The sensitivity and specificity of visual image interpretation with FDG PET was statistically significantly higher (P < .05) than with CT.
评估正电子发射断层扫描（PET）与计算机断层扫描（CT）在胰腺癌检测中的应用，并确定这些技术的定量和视觉图像解读的价值。
在手术前8周内，73例疑似胰腺癌或慢性胰腺炎患者在注射250 - 350MBq的2 - （氟 - 18） - 氟 - 2 - 脱氧 - D - 葡萄糖（FDG）后接受了CT和静态PET成像。注射后60分钟，用标准化摄取值（SUV）计算被视为恶性征象的局灶性FDG摄取。
FDG PET正确诊断出43例患者中的41例（95%）为胰腺癌，30例患者中的27例（90%）为慢性胰腺炎。SUV临界值为1.53时，检测恶性肿瘤的敏感性和特异性均为93%。CT正确诊断出41例患者中的33例（80%）为胰腺癌，而27例慢性胰腺炎患者中有7例（26%）结果为假阳性（特异性为74%）。
FDG PET能够可靠地区分胰腺腺癌与慢性胰腺炎。FDG PET视觉图像解读的敏感性和特异性在统计学上显著高于CT（P < .05）。
