Modic M T, Ross J S, Obuchowski N A, Browning K H, Cianflocco A J, Mazanec D J
Division of Radiology, Cleveland Clinic Foundation, OH 44195, USA.
Radiology. 1995 May;195(2):429-35. doi: 10.1148/radiology.195.2.7724762.
To prospectively study clinical findings and contrast material-enhanced magnetic resonance (MR) images over time in patients with acute lumbar radiculopathy.
Twenty-five patients underwent physical examination and MR imaging at presentation, 6 weeks, and 6 months. Initial symptoms and clinical course were correlated with type, size, location, and enhancement of disk herniations.
Eighteen patients had a herniated nucleus pulposus (HNP) at one or more levels, two had synovial cysts and stenosis, and five had normal findings. Patients with an HNP had marginally more severe neurologic symptoms than did patients without an HNP (P = .07) at presentation. Twenty-two patients completed the 6-week examinations and 14 patients the 6-month examinations; three patients were eliminated from the study after surgical treatment. Among HNPs larger than 6 mm, substantial reduction in size was noted in 36% at 6 weeks and in more than 60% at 6 months after presentation.
Agreement between clinical and MR findings for level and side of HNP and radicular symptoms was excellent. There was no correlation of pain and disability with disk size, behavior, or type.
前瞻性研究急性腰椎神经根病患者的临床发现以及随时间变化的对比剂增强磁共振(MR)图像。
25例患者在就诊时、6周和6个月时接受了体格检查和MR成像。将初始症状和临床病程与椎间盘突出的类型、大小、位置及强化情况进行关联分析。
18例患者在一个或多个节段出现椎间盘髓核突出(HNP),2例出现滑膜囊肿和狭窄,5例检查结果正常。就诊时,有HNP的患者神经症状比无HNP的患者略严重(P = 0.07)。22例患者完成了6周检查,14例患者完成了6个月检查;3例患者在手术治疗后退出研究。在大于6 mm的HNP中,出现后6周时36%的HNP体积显著缩小,6个月时超过60%的HNP体积显著缩小。
HNP的节段和侧别以及神经根症状的临床和MR表现之间一致性良好。疼痛和功能障碍与椎间盘大小、变化情况或类型无相关性。