Rajić M, Bogićević M, Stefanović V
Institute of Nephrology and Haemodialysis, University Clinical Centre, Nish.
Srp Arh Celok Lek. 1993 Aug-Dec;121(8-12):113-6.
In order to evaluate tubular function 99mTc-DMS dynamic kidney scintigraphy and 99mTc-DMS uptake determinations were performed in 55 patients with endemic nephropathy, diabetic nephropathy and glomerulo nephritis. From 64-656th segment of computerized radiorenograms 99mTc-DMS uptake and curve slope were assessed and compared with the corresponding parameters of 20 healthy subjects. Both parameters were decreased in patients of all three groups. Tubular uptake of 99mTc-DMS measured during 60 sec. 4 hours after 99mTc-DMS administration, was decreased in endemic nephropathy and diabetic nephropathy, but without a significant difference in glomerulonephritic patients. The study of the relationship between 4 hour 99mTc-DMS tubular fixation and glomerular filtration rate, estimated by 99mTc-DTPA clearance, showed a positive correlation only in patients with diabetic nephropathy. Patients with renal failure from all three groups had more seriously impaired tubular handling of 99mTc-DMS, that correlated with reduction of the glomerular filtration rate. The present data showed more severe impairment of tubular function in patients with endemic nephropathy and diabetic nephropathy than in glomerulonephritic patients. The method was suitable for estimation of the tubular function.
为评估肾小管功能，对55例患有地方性肾病、糖尿病肾病和肾小球肾炎的患者进行了99mTc-DMS动态肾闪烁显像及99mTc-DMS摄取测定。从计算机放射性肾图的第64至656段评估99mTc-DMS摄取和曲线斜率，并与20名健康受试者的相应参数进行比较。所有三组患者的这两个参数均降低。在注射99mTc-DMS后4小时的60秒内测量的99mTc-DMS肾小管摄取，在地方性肾病和糖尿病肾病患者中降低，但在肾小球肾炎患者中无显著差异。通过99mTc-DTPA清除率估算的4小时99mTc-DMS肾小管固定与肾小球滤过率之间的关系研究表明，仅在糖尿病肾病患者中有正相关。所有三组肾衰竭患者的99mTc-DMS肾小管处理受损更严重，这与肾小球滤过率降低相关。目前的数据表明，地方性肾病和糖尿病肾病患者的肾小管功能损害比肾小球肾炎患者更严重。该方法适用于评估肾小管功能。
