从墨西哥毒蝎（Centruroides infamatus infamatus Koch）毒液中分离出一种毒素，该毒素可改变鸡背根神经节细胞上的钠离子通透性。
Isolation of a toxin from Centruroides infamatus infamatus Koch scorpion venom that modifies Na+ permeability on chick dorsal root ganglion cells.
作者信息
Dehesa-Dávila M, Martin B M, Nobile M, Prestipino G, Possani L D
机构信息
Departmento de Bioquímica, National Autonomous University of Mexico, Cuernavaca, Morelos.
出版信息
Toxicon. 1994 Dec;32(12):1487-93. doi: 10.1016/0041-0101(94)90307-7.
A novel toxin was isolated and characterized from the venom of the Mexican scorpion Centruroides infamatus infamatus. It has an apparent mol. wt of 7600, compatible with the presence of 66 amino acid residues per molecule. The N-terminal amino acid sequence was determined (up to residue 48) and showed approximately 95% similarity with toxins from other Mexican scorpions of the gnus Centruroides. Experiments conducted with chick dorsal root ganglion cells showed that toxin 1 is a Na+ channel effector, causing a decrease in the peak Na+ permeability, similar to decreases observed for typical beta-scorpion toxins.
从墨西哥蝎子Centruroides infamatus infamatus的毒液中分离并鉴定出一种新型毒素。其表观分子量为7600，与每个分子存在66个氨基酸残基相符。测定了N端氨基酸序列（至第48位残基），结果显示它与Centruroides属其他墨西哥蝎子的毒素具有约95%的相似性。对鸡背根神经节细胞进行的实验表明，毒素1是一种Na+通道效应物，可导致Na+通透性峰值降低，这与典型的β-蝎毒素所观察到的降低情况相似。
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