Vermylen J
Pathol Biol (Paris). 1975 Dec;23 suppl:5-10.
This review summarizes the physical and chemical properties of normal factor VIII (antihaemophilic factor). Special attention is given to the different subunits of this molecule, obtained after dissociation by beta-mercaptoethanol, high or low ionic strength. Present points of controversy are outlined. A description is given of the role of factor VIII in coagulation, as it is presently understood. The studies of the physical and chemical properties of haemophilic factor VIII also are reviewed; the molecular defect of haemophilic factor VIII remains to be identified.
本综述总结了正常因子VIII（抗血友病因子）的物理和化学性质。特别关注了该分子在通过β-巯基乙醇、高或低离子强度解离后得到的不同亚基。概述了目前存在争议的要点。按照目前的理解，描述了因子VIII在凝血中的作用。还综述了血友病因子VIII的物理和化学性质研究；血友病因子VIII的分子缺陷仍有待确定。
