Christenson J T, Thulesius O, Nazzal M M
Department of Surgery, Faculty of Medicine, Kuwait University.
Vasa. 1995;24(1):56-61.
Forskolin, a diterpene obtained from coleus forskolii, is a potent cAMP stimulator. We have evaluated the effects of forskolin on blood flow, platelet aggregation and metabolism. It was found that forskolin has a dose dependent vaso-relaxing effect in an in vivo sheep model, when infused intra-arterially. Furthermore forskolin, in a dose-dependent fashion reduced whole blood platelet aggregation and ATP release. Pretreatment of PTFE grafts with Forskolin significantly reduced platelet consumption 3 hours postoperatively and on the first postoperative day. The overall platelet metabolism, measured by a microcalorimetric technique after treatment with forskolin in vitro and ex-vivo postoperatively was significantly increased.
Forskolin affects blood flow and platelet parameters favourably in the setting of occlusive arterial disease and reconstructive arterial surgery.
毛喉素是从毛喉鞘蕊花中提取的一种二萜类化合物，是一种强效的环磷酸腺苷（cAMP）刺激剂。我们评估了毛喉素对血流、血小板聚集和代谢的影响。研究发现，在体内绵羊模型中动脉内输注毛喉素时，它具有剂量依赖性的血管舒张作用。此外，毛喉素以剂量依赖方式降低全血血小板聚集和三磷酸腺苷（ATP）释放。用毛喉素预处理聚四氟乙烯（PTFE）移植物可显著降低术后3小时和术后第一天的血小板消耗。术后体外和体内用毛喉素处理后，通过微量量热技术测量的总体血小板代谢显著增加。
在闭塞性动脉疾病和动脉重建手术中，毛喉素对血流和血小板参数有有利影响。
