Christenson J T, Thulesius O, Nazzal M
Department of Surgery, Faculty of Medicine, Kuwait University, Safat.
Vasa. 1990;19(4):315-9.
Ten prosthetic polytetrafluoroethylene grafts (50 mm length, i.d. 4 mm) were surface treated with a 0.01% C-14-forskolin solution prior to interposition in the femoral arteries of 5 Australian sheep. The following parameters were monitored: femoral artery blood flow, platelet aggregation, C-14 blood and graft activity measured at intervals up to 120 minutes after declamping (DC). There was only a slightly decreased platelet aggregation in arterial blood samples 30 min. after DC and no changes in blood flow. After an initial peak C-14-forskolin graft activity declined rapidly during the first 30 minutes, thereafter only very slowly. C-14-forskolin blood activity also showed an initial peak and thereafter a fairly steady level 20-120 minutes after DC. These results are discussed in relation to previously very encouraging results in improving graft patency using an identical protocol of graft treatment with forskolin.
将10个聚四氟乙烯人工血管（长度50毫米，内径4毫米）在植入5只澳大利亚绵羊的股动脉之前，用0.01%的C-14-福司可林溶液进行表面处理。监测了以下参数：股动脉血流量、血小板聚集情况，以及在松开血管夹（DC）后长达120分钟的间隔时间测量的C-14血液和人工血管活性。在DC后30分钟时，动脉血样本中的血小板聚集仅略有下降，血流量无变化。C-14-福司可林人工血管活性在最初出现一个峰值后，在最初30分钟内迅速下降，此后下降非常缓慢。C-14-福司可林血液活性也显示出一个初始峰值，然后在DC后20 - 120分钟内保持相当稳定的水平。结合之前使用相同的福司可林人工血管处理方案在改善人工血管通畅性方面取得的非常令人鼓舞的结果，对这些结果进行了讨论。
