Koul P A, Quadri M I, Wani J I, Wahid A, Shaban M
Department of Internal Medicine, Institute of Medical Sciences, Soura, Srinagar, Kashmir, India.
Acta Haematol. 1995;93(1):13-9. doi: 10.1159/000204083.
Twenty-five consecutive patients with multidrug-resistant enteric fever were evaluated and followed for haemostatic abnormalities. Twenty-one (84%) of the patients had evidence of disseminated intravascular coagulation (DIC) and 12 (48%) also had evidence of associated fibrinolysis. Clinical bleeding was observed in 3 (12%) cases, and did not bear any correlation with clotting abnormalities. Protein C activity was found to be decreased in 11 of the 15 cases with DIC, and a block in its activation, as previously postulated, could not be substantiated. DIC was reversed in most cases within 8 days of the institution of specific antibiotic therapy.
对25例连续性耐多药肠热症患者进行了评估，并对其止血异常情况进行了随访。其中21例（84%）患者有弥散性血管内凝血（DIC）证据，12例（48%）患者还有相关纤维蛋白溶解证据。3例（12%）患者出现临床出血，且与凝血异常无任何关联。在15例DIC患者中，有11例蛋白C活性降低，且如之前所推测的，其激活受阻无法得到证实。在开始使用特异性抗生素治疗后的8天内，大多数病例的DIC得到了逆转。
