Lewis B, Jarvi E, Cady P
AANA J. 1994 Jun;62(3):257-60.
The purpose of this study was to compare daily changes in the concentration of atropine or ephedrine sulfate solutions that had been stored up to 4 days in plastic or glass syringes. Sets of three plastic and one glass syringe were used for each drug; the glass syringes acted as controls. Each set of syringes was labeled as day 0, 1, 2, 3, or 4. Syringes with medication were laid horizontally, had needles attached, and were stored in the dark at an ambient temperature. Each day, the assigned set of syringes was analyzed by high-performance liquid chromatography. Results showed that the change in the ephedrine sulfate concentration in the plastic syringes from day 0 to day 4 was less than 1.4%. Atropine sulfate decreased 52% over 4 days, with the largest single drop occurring during the first 24 hours. It can be concluded that the two brands of ephedrine sulfate stored up to 4 days at ambient temperature in the brand of syringe used do not significantly decrease in concentration. However, this was not the case with the brand of atropine sulfate studied. The practice of storing atropine sulfate in plastic syringes should be discouraged, because of the possibility of loss of potency due to medication adsorption to syringe plastic.
本研究的目的是比较在塑料或玻璃注射器中储存长达4天的阿托品或硫酸麻黄碱溶液浓度的每日变化。每种药物使用三组塑料注射器和一组玻璃注射器；玻璃注射器作为对照。每组注射器分别标记为第0、1、2、3或4天。装有药物的注射器水平放置，连接针头，并在室温下避光保存。每天，对指定的一组注射器进行高效液相色谱分析。结果表明，塑料注射器中硫酸麻黄碱浓度从第0天到第4天的变化小于1.4%。硫酸阿托品在4天内下降了52%，最大的单次下降发生在前24小时内。可以得出结论，在所使用的注射器品牌中，两种品牌的硫酸麻黄碱在室温下储存长达4天，其浓度没有显著降低。然而，所研究的硫酸阿托品品牌并非如此。由于药物可能吸附到注射器塑料上而导致效力丧失，应避免将硫酸阿托品储存在塑料注射器中的做法。
