Geelen C P, Hordijk G J, Ravasz L A, Terhaard C H
Department of Otorhinolaryngology, University Hospital Utrecht, The Netherlands.
Acta Otorhinolaryngol Belg. 1995;49(1):1-4.
Degree of tumour differentiation as a prognostic factor in advanced laryngeal cancer. As part of a retrospective analysis on treatment results in 139 patients with advanced laryngeal squamous cell carcinoma (T3-4) differentiation grade of the tumour was analyzed as a prognostic factor. Univariate analysis differentiation grade was related to tumour size, presence of neck node metastasis and conversion of N-stage during follow-up. For statistical analysis, patients with G1-G2 and G3-G4 were grouped. Prognosis for G3-G4 carcinomas is significantly worse for disease specific survival (p < 0.025), due to significantly more regional recurrence (p = 0.05). At multivariate analysis it turned out that regional control and disease specific survival in patients with no palpable neck nodes were adversely affected by the histological degree of differentiation of the diagnostic biopsy. For this group of patients extensive treatment of neck nodes is recommended.
肿瘤分化程度作为晚期喉癌的预后因素。作为对139例晚期喉鳞状细胞癌（T3 - 4）患者治疗结果的回顾性分析的一部分，肿瘤的分化程度被作为预后因素进行分析。单因素分析显示，分化程度与肿瘤大小、颈部淋巴结转移的存在以及随访期间N分期的转变有关。为进行统计分析，将G1 - G2和G3 - G4的患者分组。G3 - G4癌患者的疾病特异性生存率显著更差（p < 0.025），这是由于区域复发明显更多（p = 0.05）。多因素分析表明，对于无可触及颈部淋巴结的患者，诊断性活检的组织学分化程度对区域控制和疾病特异性生存有不利影响。对于这组患者，建议对颈部淋巴结进行广泛治疗。
