In vitro biopharmaceutical investigation of antacid activity in standard dissolution test apparatus.

The pH stat titration and the Rossett-Rice test used especially for the reaction kinetical and in vitro biopharmaceutical investigation of antacids were standardized applying the U.S.P. Dissolution Test Apparatus with paddle stirring element. The developed "artificial stomach" is suitable to simulate also the gastric emptying. The in vitro model may give a new alternative for the in vitro evaluation of antacid effectiveness, because this standardized method may perfectly eliminate the deficiencies of the earlier test prescriptions.