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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Department of Biochemistry and Molecular Biology, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark, USA.

Adv Exp Med Biol. 1994;364:115-8. doi: 10.1007/978-1-4615-2510-3_12.

1,25-Dihydroxyvitamin D3, the biologically active form of vitamin D, in addition to regulating calcium homeostasis, also has antiproliferative and prodifferentiating effects. 2. Most studies concerning the therapeutic potential of analogs of 1,25(OH)2D3, which are antiproliferative and prodifferentiating but do not cause hypercalcemia, have been done using leukemic cells. 3. Recent evidence from both in vivo and in vitro studies has indicated that 1,25(OH)2D3 or analogs of 1,25(OH)2D3 can inhibit the growth of breast cancer cells, thus suggesting the therapeutic potential of analogs of 1,25(OH)2D3 in the treatment of breast cancer.

1,25 - 二羟基维生素D3是维生素D的生物活性形式，除了调节钙稳态外，还具有抗增殖和促分化作用。2. 大多数关于1,25(OH)2D3类似物治疗潜力的研究，这些类似物具有抗增殖和促分化作用但不会引起高钙血症，都是使用白血病细胞进行的。3. 来自体内和体外研究的最新证据表明，1,25(OH)2D3或1,25(OH)2D3类似物可以抑制乳腺癌细胞的生长，因此表明1,25(OH)2D3类似物在乳腺癌治疗中的治疗潜力。

Department of Biochemistry and Molecular Biology, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark, USA.

Adv Exp Med Biol. 1994;364:115-8. doi: 10.1007/978-1-4615-2510-3_12.

1,25-Dihydroxyvitamin D3, the biologically active form of vitamin D, in addition to regulating calcium homeostasis, also has antiproliferative and prodifferentiating effects. 2. Most studies concerning the therapeutic potential of analogs of 1,25(OH)2D3, which are antiproliferative and prodifferentiating but do not cause hypercalcemia, have been done using leukemic cells. 3. Recent evidence from both in vivo and in vitro studies has indicated that 1,25(OH)2D3 or analogs of 1,25(OH)2D3 can inhibit the growth of breast cancer cells, thus suggesting the therapeutic potential of analogs of 1,25(OH)2D3 in the treatment of breast cancer.

1,25 - 二羟基维生素D3是维生素D的生物活性形式，除了调节钙稳态外，还具有抗增殖和促分化作用。2. 大多数关于1,25(OH)2D3类似物治疗潜力的研究，这些类似物具有抗增殖和促分化作用但不会引起高钙血症，都是使用白血病细胞进行的。3. 来自体内和体外研究的最新证据表明，1,25(OH)2D3或1,25(OH)2D3类似物可以抑制乳腺癌细胞的生长，因此表明1,25(OH)2D3类似物在乳腺癌治疗中的治疗潜力。