Sattar A A, Salpigidis G, Schulman C C, Wespes E
Service d'Urologie Hôpital Erasme, Bruxelles, Belgium.
Acta Urol Belg. 1995 Mar;63(1):53-9.
Intracavernous PO2 (mm Hg) was measured during flaccidity in 5 psychogenic impotent patients (control), in 9 patients with venous leak and in 10 patients with arterial disease. No significant difference was observed in the mean PO2 value between the control group 36.2 +/- 5.8 and patients with venous leak 35.6 +/- 6.9 or with arterial disease 34.1 +/- 6.5 at flaccidity. Ten minutes after injection of Prostaglandin E1 (PGE1), the mean value of cavernous PO2 in the control group 83.8 +/- 6.8 was significantly different (p < 0.01) from that in the venous group 67.8 +/- 8.2 and the arterial group 57.8 +/- 10.7 (p < 0.01). Using the computerized analysis and the immunohistochemical staining actin anti-actin, the mean percentage of cavernous smooth fibers was 43.3 +/- 3.6, 34.1 +/- 4.6, and 29.3 +/- 3.4 in the three groups of patients respectively. At flaccidity, the higher the PO2 value, the higher the percentage of cavernous smooth muscle fibers was detected (p < 0.05). A high correlation was observed between the increase in PO2 value after injection of PGE1 and the increase in cavernous smooth muscle content. On the other hand, the mean value of penile brachial index in the psychogenic 0.87 +/- 0.07 was significant different (p < 0.01) from the venogenic group 0.68 +/- 0.06 and the arteriogenic group 0.64 +/- 0.09 (p < 0.01). Similarly, a high correlation was detected between the increase in penile brachial index ratio and the increase in cavernous smooth muscle content. A decrease in the percentage of the intracavernous smooth muscle fibers could be explained by the low oxygen tension at flaccidity and therefore could be responsible for insufficient rigidity during erection.
对5例心因性阳痿患者（对照组）、9例静脉漏患者和10例动脉疾病患者在阴茎疲软状态下测量海绵体内氧分压（mmHg）。在疲软状态下，对照组平均氧分压值为36.2±5.8，静脉漏患者为35.6±6.9，动脉疾病患者为34.1±6.5，未观察到显著差异。注射前列腺素E1（PGE1）10分钟后，对照组海绵体内氧分压平均值为83.8±6.8，与静脉漏组的67.8±8.2和动脉疾病组的57.8±10.7有显著差异（p<0.01）。采用计算机分析和免疫组织化学染色抗肌动蛋白，三组患者海绵体平滑肌纤维的平均百分比分别为43.3±3.6、34.1±4.6和29.3±3.4。在疲软状态下，氧分压值越高，检测到的海绵体平滑肌纤维百分比越高（p<0.05）。注射PGE1后氧分压值的升高与海绵体平滑肌含量的增加之间存在高度相关性。另一方面，心因性阳痿患者阴茎肱动脉指数平均值为0.87±0.07，与静脉性阳痿组的0.68±0.06和动脉性阳痿组的0.64±0.09有显著差异（p<0.01）。同样，阴茎肱动脉指数比值的升高与海绵体平滑肌含量的增加之间也存在高度相关性。海绵体内平滑肌纤维百分比的降低可由疲软状态下的低氧张力来解释，因此可能是勃起时硬度不足的原因。
