Sattar A A, Salpigides G, Vanderhaeghen J J, Schulman C C, Wespes E
Department of Urology, Erasme Hospital, Brussels, Belgium.
J Urol. 1995 Nov;154(5):1736-9.
We studied the effect of intracavernous oxygen tension on the alteration of cavernous smooth muscle fibers in potent and impotent men.
Intracavernous oxygen tension (mm. Hg) was measured during flaccidity and 10 minutes after intracavernous prostaglandin E1 injection in psychogenic control patients, and those with venous leakage and arterial lesions. Cavernous biopsies were performed and the percent of smooth muscle fibers was analyzed objectively using immunohistochemical actin anti-actin staining. Simultaneously brachial oxygen tension (mm. Hg) was measured and the cavernous brachial oxygen tension index was then determined.
At flaccidity no significant difference was noted in oxygen tension values among the 3 groups of patients. After prostaglandin E1 injection cavernous oxygen tension and the cavernous brachial oxygen tension index in the control group were significantly different (p < 0.01) from those of the venogenic and arteriogenic groups (p < 0.01). The mean percent of cavernous smooth muscle fibers in the control group was significantly different from those of the venous leakage and arterial lesion groups (p < 0.01). There was a good correlation between the percent of cavernous muscle fibers and the value of oxygen tension before (p < 0.05) and after prostaglandin E1 injection (p < 0.01). A similar correlation was noted between cavernous muscle fibers and cavernous brachial oxygen tension index in the different groups of patients (p < 0.01).
Reduction of the intracavernous smooth muscle fibers in impotent patients could be explained by low intracavernous oxygen tension.
我们研究了阴茎海绵体内氧分压对有勃起功能和勃起功能障碍男性阴茎海绵体平滑肌纤维改变的影响。
对心因性对照患者、静脉漏患者及动脉性病变患者，在阴茎疲软状态下及海绵体内注射前列腺素E1后10分钟测量海绵体内氧分压（毫米汞柱）。进行海绵体活检，使用免疫组织化学肌动蛋白抗肌动蛋白染色客观分析平滑肌纤维百分比。同时测量肱动脉氧分压（毫米汞柱），然后计算海绵体与肱动脉氧分压指数。
在阴茎疲软状态下，三组患者的氧分压值无显著差异。注射前列腺素E1后，对照组的海绵体内氧分压及海绵体与肱动脉氧分压指数与静脉性和动脉性病变组相比有显著差异（p < 0.01）。对照组海绵体平滑肌纤维的平均百分比与静脉漏组和动脉性病变组有显著差异（p < 0.01）。海绵体肌纤维百分比与注射前列腺素E1前（p < 0.05）及注射后（p < 0.01）的氧分压值之间存在良好相关性。不同组患者的海绵体肌纤维与海绵体与肱动脉氧分压指数之间也存在类似相关性（p < 0.01）。
勃起功能障碍患者海绵体内平滑肌纤维减少可由海绵体内低氧分压来解释。
