Nguyen C, Haughton V M, Ho K C, An H S, Myklebust J B, Hasegawa T, Xu R, Harb J M
Department of Radiology, Medical College of Wisconsin, Milwaukee, USA.
AJNR Am J Neuroradiol. 1995 Feb;16(2):265-8.
To examine histopathologically the endothelium of contrast-enhancing spinal nerve roots.
In five adult baboons, chronic compression of the left S-1 spinal nerve root sufficient to produce a change in the evoked potential was produced by means of a suture tied around the nerve. The animals were studied with MR at 8 and 16 days after nerve compression and then killed for histopathologic and electron microscopic studies. Histopathologic changes in the nerve roots demonstrating contrast enhancement were described.
In all compressed spinal nerves, contrast enhancement was observed. Histopathologically, wallerian degeneration of the root and inflammation and disruption of the endothelium of capillaries in the spinal nerve were evident.
Degenerative changes in the nerve root and the capillary endothelium of a lumbar spinal nerve are associated with contrast enhancement.
通过组织病理学检查对比增强的脊神经根内皮。
在5只成年狒狒中，通过在神经周围系一根缝线对左侧S-1脊神经根进行慢性压迫，足以引起诱发电位变化。在神经受压后8天和16天对动物进行磁共振成像研究，然后处死进行组织病理学和电子显微镜研究。描述了显示对比增强的神经根的组织病理学变化。
在所有受压的脊神经中均观察到对比增强。组织病理学上，神经根的瓦勒变性以及脊神经中毛细血管内皮的炎症和破坏明显。
腰段脊神经根和毛细血管内皮的退行性变化与对比增强有关。
