Peacock J E, Blackburn A, Sherry K M, Reilly C S
Department of Surgical and Anaesthetic Sciences, University of Sheffield, Royal Hallamshire Hospital, United Kingdom.
Anesth Analg. 1995 May;80(5):1002-6. doi: 10.1097/00000539-199505000-00026.
The aim of this study was to show that blood propofol concentrations at loss of consciousness vary with the rate of administration. Eighteen patients were allocated to receive a propofol infusion at 6 or 12 mg.kg-1.h-1 (approximately 8 and 15 mg/min) for induction of anesthesia. Propofol concentrations were analyzed from simultaneous arterial and jugular bulb venous blood samples. There were no significant differences in the dose of propofol administered to induce anesthesia (0.52 mg/kg both groups). However there were significant differences between the groups in the mean induction times (309 and 156 s), and in median arterial and venous concentrations at induction. Arterial concentrations were 1.93 and 2.70 and venous 1.11 and 1.51 micrograms/mL. There were no significant differences between the groups in the area between the arterial and venous time concentration curves from start of infusion to loss of consciousness (3.14 and 3.05 micrograms.mL-1.min-1). This study confirms that a target blood concentration of propofol cannot be identified with loss of consciousness under nonsteady state conditions. Both arterial and venous blood propofol concentrations at loss of consciousness depend on the rate of administration.
本研究的目的是表明意识消失时的血丙泊酚浓度随给药速率而变化。18例患者被分配接受丙泊酚输注，输注速率为6或12mg·kg-1·h-1（约8和15mg/min）用于诱导麻醉。从同时采集的动脉血和颈静脉球部静脉血样本中分析丙泊酚浓度。诱导麻醉时给予的丙泊酚剂量两组间无显著差异（均为0.52mg/kg）。然而，两组在平均诱导时间（309和156秒）以及诱导时动脉和静脉浓度中位数方面存在显著差异。动脉浓度分别为1.93和2.70，静脉浓度分别为1.11和1.51微克/毫升。从输注开始到意识消失，两组在动脉和静脉时间浓度曲线之间的面积无显著差异（3.14和3.05微克·毫升-1·分钟-1）。本研究证实，在非稳态条件下，意识消失时无法确定丙泊酚的目标血药浓度。意识消失时动脉和静脉血丙泊酚浓度均取决于给药速率。
