Wang Y P, Cheng Y J, Fan S Z, Liu C C
Department of Anesthesiology, National Taiwan University Hospital, Taipei, Republic of China.
Anesth Analg. 1994 Dec;79(6):1148-50. doi: 10.1213/00000539-199412000-00021.
To compare the arterial and venous concentration differences of propofol, six healthy adult patients received a propofol infusion by the Bristol three-stage manual stepdown technique. Both the mean arterial and venous concentrations of propofol remained relatively stable during the 40-min infusion. Simultaneous blood sampling from the artery and vein during the infusion period resulted in arterial concentrations significantly higher than venous concentrations. This relationship was reversed after stopping the infusion. The mean +/- SD (range) venous to arterial concentration differences were -28.8% +/- 18.3% (-71% to 1.7%) during the infusion and 18.9% +/- 13.4% (-1.5% to 40.9%) after the infusion. We conclude that venous concentrations were not useful to estimate the arterial value during and after a stepdown propofol infusion. Arterial sampling is more appropriate in pharmacologic studies of propofol.
为比较丙泊酚的动脉血与静脉血浓度差异，6名健康成年患者采用布里斯托尔三阶段手动递减技术接受丙泊酚输注。在40分钟的输注过程中，丙泊酚的平均动脉血浓度和静脉血浓度均保持相对稳定。输注期间同时采集动脉血和静脉血样，结果显示动脉血浓度显著高于静脉血浓度。停止输注后，这种关系发生了逆转。输注期间静脉血与动脉血浓度差异的平均值±标准差（范围）为-28.8%±18.3%（-71%至1.7%），输注后为18.9%±13.4%（-1.5%至40.9%）。我们得出结论，在递减丙泊酚输注期间及之后，静脉血浓度无法用于估计动脉血值。在丙泊酚的药理学研究中，采集动脉血样更为合适。
