Saper J R
Postgrad Med. 1976 May;59(5):122-8. doi: 10.1080/00325481.1976.11714359.
Secondary metabolic encephalopathy is a diffuse disorder of the brain caused by an extracerebral process. Underlying causes include oxygen deprivation, systemic metabolic disease, and drug intoxication. Symptoms and signs usually suggest a generalized disturbance of brain function: alterations in the level of consciousness; diffuse and, occasionally, focal motor abnormalities; and seizures. Electroencephalography in most instances gives evidence of generalized neuronal disturbance. Early diagnosis is important because encephalopathy secondary to an extracerebral process is potentially reversible. Treatment is directed toward reversal or control of the underlying process, supportive care, and prevention of complications such as infection, electrolyte imbalance, and cerebral edema.
继发性代谢性脑病是一种由脑外病变引起的弥漫性脑部疾病。潜在病因包括缺氧、全身性代谢疾病和药物中毒。症状和体征通常提示脑功能的全身性紊乱：意识水平改变；弥漫性且偶尔为局灶性运动异常；以及癫痫发作。大多数情况下，脑电图显示存在全身性神经元紊乱。早期诊断很重要，因为脑外病变继发的脑病可能是可逆的。治疗旨在逆转或控制潜在病因、提供支持性护理并预防感染、电解质失衡和脑水肿等并发症。
