Taheri S A, Schultz R O
Angiology. 1995 Apr;46(4):299-303. doi: 10.1177/000331979504600403.
Chronic venous insufficiency is a disease that carries significant morbidity and represents a sizeable burden to the health care system. Current medical and surgical therapies are associated with a high incidence of failure. This has prompted the development of a synthetic vein valve for the treatment of chronic venous insufficiency. Nine dogs underwent the implantation of ten valves into the femoral veins. Initial studies showed the valves to be competent and patent. However, over a two-year period dense ingrowth of intimal hyperplasia rendered the valves functionless.
慢性静脉功能不全是一种发病率很高的疾病，给医疗保健系统带来了相当大的负担。目前的药物和手术治疗失败率很高。这促使人们研发一种用于治疗慢性静脉功能不全的人工静脉瓣膜。9只狗接受了将10个瓣膜植入股静脉的手术。初步研究表明这些瓣膜功能正常且通畅。然而，在两年的时间里，内膜增生的大量向内生长使瓣膜失去了功能。
