多黏菌素B刺激人单核细胞中补体成分和细胞因子的产生。
Polymyxin B stimulates production of complement components and cytokines in human monocytes.
作者信息
Høgåsen A K, Abrahamsen T G
机构信息
Department of Pediatric Research, Rikshospitalet, National Hospital, Oslo Norway.
出版信息
Antimicrob Agents Chemother. 1995 Feb;39(2):529-32. doi: 10.1128/AAC.39.2.529.
Abstract
Polymyxin B (PmB), an agent often used to neutralize the effects of bacterial lipopolysaccharide (LPS), was shown to exert a dose-dependent stimulatory effect on the biosynthesis of C3, factor B, interleukin-6 (IL-6), and granulocyte-macrophage colony-stimulating factor (GM-CSF) in human monocytes. A low dose of PmB (1 to 5 micrograms/ml) efficiently suppressed the LPS-induced (1 or 100 ng/ml) production of IL-6, GM-CSF, and factor B, but not the C3 production induced by 100 ng of LPS per ml. A reduced level of GM-CSF may have contributed to the persisting high C3 concentrations and the apparent lack of LPS inhibition in the latter situation, since GM-CSF is an inhibitor of monocyte C3 biosynthesis.
摘要
多粘菌素B（PmB）是一种常用于中和细菌脂多糖（LPS）作用的药物，研究表明它对人单核细胞中C3、B因子、白细胞介素-6（IL-6）和粒细胞-巨噬细胞集落刺激因子（GM-CSF）的生物合成具有剂量依赖性刺激作用。低剂量的PmB（1至5微克/毫升）可有效抑制LPS诱导（1或100纳克/毫升）的IL-6、GM-CSF和B因子的产生，但不能抑制每毫升100纳克LPS诱导的C3产生。GM-CSF水平降低可能导致了后者情况下C3浓度持续居高不下以及明显缺乏LPS抑制作用，因为GM-CSF是单核细胞C3生物合成的抑制剂。
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