酗酒者与乙醛脱氢酶2（ALDH2）、乙醇脱氢酶2（ADH2）、乙醇脱氢酶3（ADH3）以及细胞色素P-450 2E1（P-4502E1）基因类型之间的关联
[Association between alcoholics and the genotypes of ALDH2, ADH2, ADH3 as well as P-4502E1].
作者信息
Nakamura K, Suwaki H, Matsuo Y, Ichikawa Y, Miyatake R, Iwahashi K
机构信息
Department of Neuropsychiatry, Kagawa Medical School, Japan.
出版信息
Arukoru Kenkyuto Yakubutsu Ison. 1995 Feb;30(1):33-42.
We examined the genotypes of ALDH2, ADH2, ADH3 and P-4502E1 loci of alcoholics and nonalcoholics. Also we compared the frequencies of the homozygous ALDH21/1 genotype and heterozygous ALDH21/2 genotypes in alcoholics. Our study reported differences in the allelic frequencies of ALDH2, ADH2 and ADH3 loci between alcoholics and nonalcoholics. For alcoholics, it was indicated that ADH2 and ADH3 plays an important role for alcoholism. For genotypes of P-4502E1, no significant difference was observed between alcoholics and nonalcoholics. Alcoholics with the heterozygous ALDH21/2 genotype had significantly higher frequency of the ADH21 than that of alcoholics with ALDH21/1 genotype. Concerning the alcoholics with the heterozygous ALDH21/2 genotype, we assumed that ADH2*1 plays a role for the development of alcoholism.
我们检测了酗酒者和非酗酒者的乙醛脱氢酶2（ALDH2）、乙醇脱氢酶2（ADH2）、乙醇脱氢酶3（ADH3）和细胞色素P-450 2E1（P-4502E1）基因座的基因型。此外，我们比较了酗酒者中纯合子ALDH21/1基因型和杂合子ALDH21/2基因型的频率。我们的研究报告了酗酒者和非酗酒者之间ALDH2、ADH2和ADH3基因座等位基因频率的差异。对于酗酒者，表明ADH2和ADH3对酒精中毒起重要作用。对于P-4502E1的基因型，酗酒者和非酗酒者之间未观察到显著差异。具有杂合子ALDH21/2基因型的酗酒者中ADH21的频率显著高于具有ALDH21/1基因型的酗酒者。关于具有杂合子ALDH21/2基因型的酗酒者，我们推测ADH2*1在酒精中毒的发生中起作用。
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