Nakamura K, Iwahashi K, Suwaki H, Miyatake R, Matsuo Y, Ichikawa Y
Department of Neuropsychiatry, Kagawa Medical School, Japan.
Arukoru Kenkyuto Yakubutsu Ison. 1994 Feb;29(1):52-8.
The series were composed of 59 alcoholics. All the subjects fulfilled the DSM-III-R criteria for alcohol dependency. We investigated the genotype at ALDH2. 6 patients were heterozygous ALDH2(1)/ALDH2(2). We determined the genotypes at ADH2, ADH3 and P-4502E1 about 6 patients. 5 patients had ADH2(1)/ADH2(1) allele. 2 patients had P-450E1*C2. We found a genetic characteristic about alcoholics with the heterozygous ALDH2(1)/ALDH2(2) allele.
该系列包括59名酗酒者。所有受试者均符合DSM-III-R酒精依赖标准。我们研究了醛脱氢酶2（ALDH2）的基因型。6名患者为ALDH2(1)/ALDH2(2)杂合子。我们确定了约6名患者乙醇脱氢酶2（ADH2）、乙醇脱氢酶3（ADH3）和细胞色素P-450 2E1（P-4502E1）的基因型。5名患者具有ADH2(1)/ADH2(1)等位基因。2名患者具有P-450E1*C2。我们发现了具有ALDH2(1)/ALDH2(2)杂合子等位基因的酗酒者的遗传特征。
