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完整的α亚基对于人线粒体三功能β氧化蛋白的膜结合是必需的，但对于赋予β亚基3-酮酰基辅酶A硫解酶活性并非必要。

Intact alpha-subunit is required for membrane-binding of human mitochondrial trifunctional beta-oxidation protein, but is not necessary for conferring 3-ketoacyl-CoA thiolase activity to the beta-subunit.

作者信息

Weinberger M J, Rinaldo P, Strauss A W, Bennett M J

机构信息

Department of Pathology, University of Texas Southwestern Medical Center at Dallas 75235, USA.

出版信息

Biochem Biophys Res Commun. 1995 Apr 6;209(1):47-52. doi: 10.1006/bbrc.1995.1468.

DOI:10.1006/bbrc.1995.1468
PMID:7726862
Abstract

We have studied the activities of alpha and beta subunit enzymes of the beta-oxidation trifunctional protein complex in a patient who does not process the alpha-subunit. Long-chain 3-ketoacyl-CoA thiolase, the beta-subunit enzyme, was transported into the mitochondrial matrix, where it expressed normal levels of activity, but was not translocated to the membrane. Thus, intact alpha-subunit is required for trifunctional protein membrane translocation, but is not necessary for conferring activity of the beta-subunit.

摘要

我们研究了一位无法处理α亚基的患者体内β氧化三功能蛋白复合体的α和β亚基酶的活性。β亚基酶长链3-酮脂酰辅酶A硫解酶被转运到线粒体基质中，在那里它表现出正常水平的活性，但没有转运到膜上。因此，完整的α亚基是三功能蛋白膜转运所必需的，但对于赋予β亚基活性并非必要。

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