Knights R M, Viets C A
Pharmacol Biochem Behav. 1975 Nov-Dec;3(6):1107-14. doi: 10.1016/0091-3057(75)90024-6.
Thirty boys rated as hyperactive by their teachers and parents received penoline or placebo in a double blind design. A variety of measures were taken during the nine week blind period. Behavior ratings were made on the Conners scale at 4 time intervals showing that a significant improvement in the drug group was observed by the teachers, but no significant change occurred in the ratings by the parents and physician. No toxic or grossly abnormal results were obtained from pediatric examinations which included blood, urine and stool samples as well as height, weight and cardiovascular data. Psychological tests, including the WISC, yielded no significant findings over the 9 weeks although initial differences existed between the drug and placebo groups. These measures were also administered during the 18 month long-term phase for 14 of the children which led to the conclusion that penoline is an effective agent for improving the general behavior and school performance of some of the hyperactive boys.
30名被老师和家长评定为多动的男孩，以双盲设计接受了匹莫林或安慰剂治疗。在为期9周的盲法期内采取了多种测量方法。在4个时间间隔使用康纳斯量表进行行为评定，结果显示教师观察到药物组有显著改善，但家长和医生的评定没有显著变化。儿科检查（包括血液、尿液和粪便样本以及身高、体重和心血管数据）未得到有毒或明显异常的结果。心理测试（包括韦氏儿童智力量表）在9周内未得出显著结果，尽管药物组和安慰剂组最初存在差异。14名儿童在为期18个月的长期阶段也进行了这些测量，得出的结论是匹莫林是改善一些多动男孩总体行为和学习成绩的有效药物。
