Karasek M, Marek K, Zielinska A, Swietoslawski J, Bartsch H, Bartsch C
Department of Pathomorphology, Medical University of Lodz, Poland.
Biol Signals. 1994 Nov-Dec;3(6):302-6. doi: 10.1159/000109558.
The aim of the present study was to investigate the ultrastructure of pinealocytes and plasma melatonin concentrations in Fischer rats bearing an advanced (14th) passage 7,12-dimethylbenz[a]anthracene-induced mammary tumor. Quantitative ultrastructural analysis of the cell size and relative volumes of various cell organelles as well as the number of dense-core vesicles was performed in pinealocytes of the animals killed either during the daytime (15.00 h) or at night (3.00 h) 1 month after tumor transplantation. No significant differences between control and tumor-bearing animals were observed either during the daytime or at night. However, plasma melatonin concentrations in tumor-bearing rats killed at 3.00 h were suppressed by 35% (p < 0.025) when compared to the control animals killed at the same time.
本研究的目的是调查携带第7、12 - 二甲基苯并[a]蒽诱导的晚期（第14代）乳腺肿瘤的Fischer大鼠松果体细胞的超微结构和血浆褪黑素浓度。在肿瘤移植1个月后的白天（15:00）或夜间（03:00）处死动物，对松果体细胞的细胞大小、各种细胞器的相对体积以及致密核心囊泡的数量进行了定量超微结构分析。无论是白天还是夜间，对照动物和荷瘤动物之间均未观察到显著差异。然而，与同时处死的对照动物相比，在03:00处死的荷瘤大鼠的血浆褪黑素浓度被抑制了35%（p < 0.025）。
