Wolf R L, Olinsky A
S Afr Med J. 1976 Apr 3;50(15):574-6.
Fifty-one babies with prolonged rupture of fetal membranes (longer than 24 hours) were studied for evidence of latent infection. Cord blood was taken from all babies for a full blood count and blood culture. Gastric aspirates were collected and vernix swabs were taken immediately after delivery. Microscopy, culture and antibiotic sensitivity tests were done on the appropriate specimens. Each baby had a thorough medical examination immediately after birth, and 3 and 7 days afterwards. After the initial investigation they were allocated to a treatment (penicillin 50 000 U/kg/d and kanamycin 10 mg/kg/d) or a non-treatment group by randomised card selection. Six patients became infected, as was shown by a positive blood culture, while 4 of the 6 had clinical signs of infection as well. These infants were treated with penicillin and kanamycin, and all did well. None of the remaining babies showed any signs of infection. There were no deaths. Blood culture was found to correlate well with clinical infections, and many be used as a guide to latent infection and treatment.
对51例胎膜早破（超过24小时）的婴儿进行了潜在感染证据的研究。采集所有婴儿的脐带血进行全血细胞计数和血培养。分娩后立即收集胃吸出物并采集胎脂拭子。对适当的标本进行显微镜检查、培养和抗生素敏感性试验。每个婴儿在出生后、出生后3天和7天均进行了全面的体格检查。初始调查后，通过随机抽牌将他们分为治疗组（青霉素5万U/kg/d和卡那霉素10mg/kg/d）或非治疗组。6例患者血培养呈阳性，表明发生感染，其中6例中有4例同时有感染的临床体征。这些婴儿接受了青霉素和卡那霉素治疗，效果良好。其余婴儿均未出现任何感染迹象。无死亡病例。发现血培养与临床感染相关性良好，可作为潜在感染和治疗的指导。
